A published study by the Journal of Nutrition and Disease on how Wax Ester from Calanus® oil reduce diet-induced obesity and related metabolic disorders in mice

A published study by the Journal of Nutrition and Disease on how Wax Ester from Calanus® oil reduce diet-induced obesity and related metabolic disorders in mice

Summary of the Scientific Study:

Research study reported that dietary supplementation with oil from the marine zooplankton Calanus finmarchicus (Calanus oil) attenuates obesity, inflammation, and glucose intolerance in mice. More than 80% of Calanus oil consists of wax esters, i.e., long-chain fatty alcohols linked to long-chain fatty acids. In the present study, we compared the metabolic effects ofCalanus oil-derived wax esters (WE)with those ofpurified eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) ethyl esters (E/D) in a mouse model of diet-induced obesity. C57BL/6J mice received a high-fat diet (HFD; 45% energy from fat). 

Discussion

The scientists reported recently that dietary supplementation with oil from the marine zooplankton C. finmarchicus reduces diet-induced obesity and attenuates obesity-related metabolic disorders in mice (3). The biochemical composition of this oil is notably different from that of other marine oils, containing ~80% wax esters, i.e., aliphatic long-chain fatty alcohols esterified to saturated or unsaturated FAs. In the present study, we show that dietary supplementation with theCalanusoil-derived wax ester (WE) exerts similar effects as the crude oil. When compared with E/D, the former showed a superior effect. 

 

Collectively, the data from the present study show thatCalanus oil-derived wax esters (WE) are superior to the ethyl esters of purified EPA + DHA. The biochemical differences of the 2 preparations, in terms of either esterification to an ethyl group (E/D) vs. a long-chain fatty alcohol (WE) or their different FA composition could possibly account for the observed differences between these 2 groups. 

If you want a complete copy of the study, please send an email to info@rubyofthesea.com. We would be happy to provide it for you.

References: 

Höper, A.C., Salma, W., Sollie, S.J., Hafstad, A.D., Lund, J., Khalid, J., Raa, J., Aasum, E. & Larsen,T.S. (2014). Wax Esters from the Marine Copepod Calanus finmarchicus Reduce Diet-Induced Obesity and Obesity-Related Metabolic Disorders in Mice. Journal of Nutrition, 144 (2): 164-169

Search